Role of Angiotensin II in the Pathogenesis of Hyperdipsia in Chronic Renal Failure
- Toshihide Yamamoto, MD;
- Masanori Shimizu, MD;
- Masahiro Morioka, MD;
- Mitsuo Kitano, MD;
- Hirokazu Wakabayashi, MD;
- Nobuyuki Aizawa, MD
Abstract
The relation of thirst to the renin-angiotensin system was examined in 38 patients with chronic renal failure receiving hemodialysis treatment. They were classified into three groups, ie, group 1(19 patients), no or modest thirst; group 2 (13 patients), moderate thirst; and group 3 (six patients), excessive thirst. The plasma renin activity, plasma angiotensin II levels, and interdialytic weight gains of groups 1 to 3 significantly increased in a progressive manner with intensity of thirst. The hyperdipsia experienced by four patients in group 3 ameliorated after administration of an angiotensin-converting-enzyme inhibitor. The hyperdipsia of some patients with chronic renal failure therefore appears to be mediated by increased production of endogenous angiotensin II.
(JAMA 1986;256:604-608)
Footnotes
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Presented in part at the 15th International Congress of the International Society of Psychoneuroendocrinology, Vienna, July 17, 1984.
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Reprint requests to the Department of Internal Medicine, Kishiwada Tokushukai Hospital, 4-22-38 Isonokamicho, Kishiwada, Osaka 596, Japan (Dr Yamamoto).
