Human Papillomavirus Types and Recurrent Cervical Warts
- Gerard J. Nuovo, MD;
- Bader M. Pedemonte, MD
- From the Department of Pathology and the Cancer Research Center, Columbia Presbyterian Medical Center (Dr Nuovo), and the Department of Pathology, Harlem Hospital Medical Center (Dr Pedemonte), New York, NY. Dr Nuovo is a paid consultant for Life Technologies Inc, the company that makes the in situ hybridization kit used in the study.
Abstract
We analyzed cervical intraepithelial neoplasias (CINs) detected after cryotherapy to determine if recurrence is associated with the same human papillomavirus (HPV) type found in the original lesion. Eight women had detectable HPV DNA in CINs that occurred after ablation of another CIN, and for each patient the HPV type in the pretreatment lesion was different from that in the CIN that appeared after cryotherapy. This compares with 12 women who had HPV detected in two or more CINs present at the same time, 11 of whom had the same HPV type noted. We concluded that although multiple, simultaneous CINs in a woman often contain the same HPV type, recurrent CINs that occur after cryotherapy contain an HPV type different from that present in the pretreatment lesion.
(JAMA. 1990;263:1223-1226)
Footnotes
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Reprint requests to Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794-8691 (Dr Nuovo).
