Intradermal vs Intramuscular Hepatitis B Vaccinations-Reply
- Jessica Anne Clarke, MD, PhD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
In Reply.— We applaud the well-designed study by Wiström et al that demonstrates that low-dose ID inoculation of adults with three 2-μg doses of a recombinant hepatitis B vaccine (Recombivax-HB, Merck Sharp & Dohme) results in lower seroconversion rates and reduced levels of antibody to HBsAg compared with three 10-μg IM injections of the same product.
These results are not unexpected. There is a positive correlation between dose and immune response regardless of the type of product used.1 In our ID study we were able to use the more immunogenic plasma-derived Hepta
