Insulin-like Growth Factor and Apolipoprotein B
- Richard E. Ostlund, Jr, MD;
- Myrlene A. Staten, MD;
- Wendy M. Kohrt, PhD;
- Kathleen A. Obert, RD;
- William H. Daughaday, MD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
To the Editor. —Apolipoprotein B (apo B) is the principal protein component of the atherogenic lipoproteins low-density (LDL) and very-low-density (VLDL). The factors that regulate plasma apo B levels are of particular interest since in some data apo B is more closely related to coronary heart disease than LDL or VLDL cholesterol.1 We wondered whether insulin-like growth factor I (IGF-I) might be such a factor since the infusion of recombinant IGF-I recently was reported to lower plasma cholesterol levels.2-4 Indeed, previous work had shown that IGF-I deficiency states were accompanied by hypercholesterolemia.5-7 Our hypothesis was that apo B—containing lipoproteins were inversely related to circulating IGF-I in normal subjects.
Insulin-like growth factor I,8 insulin-like growth factor II (IGF-II),9 and apo B10 were measured in serum frozen at —70° obtained from 148 well-characterized, healthy men and women between the ages of 60 and 70 years for
