Hepatitis C Virus Infection Among Patients Attending a Clinic for Sexually Transmitted Diseases
- Hillard S. Weinstock, MD;
- Gail Bolan, MD;
- Arthur L. Reingold, MD;
- Louis B. Polish, MD
- From the Division of STD/HIV Prevention (Dr Weinstock) and Hepatitis Branch, Division of Viral and Rickettsial Diseases (Dr Polish), Centers for Disease Control and Prevention, Atlanta, Ga; San Francisco Department of Public Health and the Department of Medicine, University of California, San Francisco (Dr Bolan); and School of Public Health, University of California, Berkeley (Dr Reingold).
Abstract
Objective. —To evaluate the association between hepatitis C virus (HCV) infection and sexual behavior in a sexually active population.
Design. —Cross-sectional study.
Setting. —Inner-city clinic for sexually transmitted diseases.
Subjects. —The study included 1292 patients attending the clinic for care during a 1-month period and having syphilis serologic tests performed.
Outcome Measures. —Antibody to HCV (anti-HCV) positivity as defined by a repeatedly reactive enzyme immunoassay and a positive neutralization enzyme immunoassay (Abbott Laboratories, Chicago, Ill).
Results. —Of 1292 patients screened for anti-HCV, 99 (7.7%) were positive. Logistic regression analysis found that patients who reported intravenous drug use, were positive for antibody to hepatitis B core antigen, reported a history of a blood transfusion, were black, or reported crack cocaine use were more likely to be anti-HCV-positive. Forty-five percent of patients who were anti-HCV-positive reported intravenous drug use. Sex with an intravenous drug user and a history of gonorrhea and syphilis were associated with anti-HCV positivity in a univariate analysis, but after controlling for confounding variables, no such associations remained. While having multiple sexual partners in the previous 3 months, being homosexual or bisexual, and engaging in receptive anal intercourse were associated with being positive for antibody to hepatitis B core antigen, those behaviors were not associated with anti-HCV positivity.
Conclusions. —While these results cannot exclude a role for the sexual transmission of HCV, they do suggest that, in this sexually active population, the sexual transmission of HCV occurs infrequently and that HCV is largely associated with intravenous drug use.
(JAMA. 1993;269:392-394)
Footnotes
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Presented, in part, at the 31st Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Ill, September 30, 1991.
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