Nitric Oxide and Septic Shock
- J. Perren Cobb, MD;
- Robert L. Danner, MD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
Case 1 A 23-year-old woman presented with a 2-week history of bruising and fever. She was diagnosed as having acute myelogenous leukemia. Three days after beginning chemotherapy, she became disoriented and hypotensive. Her platelet count was 60×109/L, and her white blood cell count was 1.0×109/L, with an absolute neutrophil count of 0.48×109/L. She was resuscitated with 3 L of saline and she was given dopamine at 5 μg·kg-1·min-1 and broad-spectrum antibiotics. Her chest radiograph revealed diffuse interstitial-alveolar infiltrates. She required mechanical ventilation for progressive hypoxemia. Pulmonary and radial arterial catheters were inserted and the following hemodynamic parameters were obtained: blood pressure, 90/35 mm Hg; mean arterial pressure (MAP), 53 mm Hg; heart rate, 124 beats per minute; cardiac index, 7.8 L·min-1·m-2; central venous pressure (CVP), 12 mm Hg; pulmonary artery pressure, 42/28 mm Hg; pulmonary capillary
Footnotes
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Reprints: Robert L. Danner, MD, Critical Care Medicine Department, Warren G. Magnuson Clinical Center, Bldg 10, Room 7D-43, National Institutes of Health, Bethesda, MD 20892.
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Grand Rounds at the Clinical Center of the National Institutes of Health section editors: John I. Gallin, MD, the Clinical Center of the National Institutes of Health, Bethesda, Md; David S. Cooper, MD, Contributing Editor, JAMA.
