Neonatal Signs After In Utero Exposure to Selective Serotonin Reuptake Inhibitors—Reply
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mosesel@upmc.edu
- Debra Bogen, MD;
- James Perel, PhD;
- Katherine L. Wisner, MD, MS
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University of Pittsburgh School of Medicine
Pittsburgh, Pa
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Princeton University
Princeton, NJ
- Kathleen Uhl, MD;
- Bob Levin, MD
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Center for Drug Evaluation and Research
US Food and Drug Administration
Rockville, Md
Since this article does not have an abstract, we have provided the first 150 words of the full text.
In Reply: We appreciate the distinction between the timing of the SSRI-associated neonatal behavioral syndrome and that of infantile colic made by Dr Kaye and Ms Weinstein. We made this analogy because of the commonality of signs that comprise the SSRI-associated neonatal behavioral syndrome and colic (irritability and crying). Our intention was to place the SSRI-associated neonatal behavioral syndrome in the context of other mild, non–life-threatening syndromes that are familiar to a general audience. The statement that pregnant women should not discontinue their SSRIs to prevent colic or blame themselves for causing colic is a very important contribution to this discussion.
We were interested to learn from Dr Lavenstein of an additional 3 cases that follow the pattern and support the self-limited nature of the SSRI-associated neonatal behavioral syndrome described in our review. We would like to clarify that late-gestational fluoxetine, because of its long half-life, is likely to lead …
