Genes Involved in the Pathogenesis of Primary Open-Angle Glaucoma
In Search of the Holy Grail
- Louis R. Pasquale, Commentary by, MD
- Author Affiliations: Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Mass.
- Corresponding Author: Louis R. Pasquale, MD, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114 (louis_pasquale{at}meei.harvard.edu).
Since this article does not have an abstract, we have provided the first 150 words of the full text.
- KEYWORDS:
- GENETIC PREDISPOSITION TO DISEASE
- GLAUCOMA, OPEN-ANGLE
- INTRAOCULAR PRESSURE
- OCULAR HYPERTENSION
Archives of Ophthalmology
Identification of Novel Genetic Loci for Intraocular Pressure: A Genomewide Scan of the Beaver Dam Eye Study
Priya Duggal, MD, MPH; Alison P. Klein, PhD; Kristine E. Lee, MS; Ronald Klein, MD, MPH; Barbara E. K. Klein, MD, MPH; Joan
E. Bailey-Wilson, PhD
Objective: To identify genetic loci that control intraocular pressure (IOP).
Methods: We performed a genomewide scan of IOP, using 486 pedigrees ascertained through a population-based cohort, the Beaver Dam
Eye Study. Linkage analysis was performed using the modified Haseman-Elston regression models and variance components linkage
analysis.
Results: Seven regions of interest were identified on chromosomes 2, 5, 6, 7, 12, 15, and 19. The novel linkage region on chromosome
19p had an empirical multipoint P value of 6.1 × 10−5. Two of the regions (2 and 19) were especially interesting since each has been identified as a potential linkage region for
blood pressure.
Conclusions: …
