Rapid Dissection of the Genetic Risk of Age-Related Macular Degeneration
Achieving the Promise of the Genomic Era
- Jonathan L. Haines, Commentary by, PhD;
- Margaret A. Pericak-Vance, PhD
- Author Affiliations: Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn (Dr Haines) and Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Fla (Dr Pericak-Vance).
- Corresponding Author: Margaret A. Pericak-Vance, PhD, Miami Institute for Human Genomics, University of Miami, Miller School of Medicine, PO Box 019132, Miami, FL 33101 (mpericak{at}med.miami.edu).
Since this article does not have an abstract, we have provided the first 150 words of the full text.
- KEYWORDS:
- AGING
- COMPLEMENT FACTOR H
- GENETIC PREDISPOSITION TO DISEASE
- GENOMICS
- MACULAR DEGENERATION
- RISK FACTORS
ARCHIVES OF OPHTHALMOLOGY
A Prospective Study of 2 Major Age-Related Macular Degeneration Susceptibility Alleles and Interactions With Modifiable Risk
Factors
Debra A. Schaumberg, ScD, OD, MPH; Susan E. Hankinson, ScD; Qun Guo, MSc; Eric Rimm, ScD; David J. Hunter, MBBS, ScD
Objectives To delineate the magnitude of susceptibility to age-related macular degeneration (AMD) due to common variants in the gene
for complement factor H (CFH) and the predicted gene LOC387715 and to determine whether these variants interact with modifiable risk factors.
Methods We compared cases who developed AMD (n = 457) with 1071 age- and sex-matched control subjects in a prospective nested case-control
study within the Nurses' Health Study and the Health Professionals Follow-up Study. We determined the incidence rate ratios
and 95% confidence intervals (CIs) for AMD for each genotype and examined the interactions with modifiable risk factors.
Results Participants with 1 or 2 copies of the Y402H variant of CFH …
