Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men
- Rasmus H. Olsen, MD;
- Rikke Krogh-Madsen, MD krogh-madsen@inflammation-metabolism.dkCentre of Inflammation and Metabolism;
- Carsten Thomsen, MD, DMScDepartment of RadiologyRigshospitaletUniversity of CopenhagenCopenhagen, Denmark;
- Frank W. Booth, PhDHealth Activity CenterDepartment of Biomedical SciencesUniversity of MissouriColumbia;
- Bente K. Pedersen, MD, DMScCentre of Inflammation and MetabolismRigshospitaletUniversity of Copenhagen
Since this article does not have an abstract, we have provided the first 150 words of the full text.
- KEYWORDS:
- EXERCISE
- INSULIN
- LIPIDS
- MEN'S HEALTH
- METABOLISM
- MOTOR ACTIVITY
To the Editor: Increased daily physical activity is associated with improved health,1 but it is uncertain whether it prevents initial metabolic events that produce chronic diseases. We are aware of no evidence in healthy, young adults that reduced daily stepping within a free-living environment is associated with negative metabolic consequences. The purpose of this study was to reduce daily steps and assess metabolic changes.
Methods
Participants were recruited for 2 substudies by advertisement and received compensation. Inclusion criteria were asymptomatic nonsmokers without family history of diabetes mellitus, medication use, or physical abnormalities; exclusion criteria were walking fewer than 3500 steps per day measured over 1 week (Yamax Digi-Walker SW-200 pedometer; Great Performance Ltd, London, United Kingdom) or performing more than 2 hours of regular exercise per week. The studies were approved by the local scientific-ethical committee, and participants provided written informed consent.
Participants were instructed to reduce daily steps by …
