Crohn Disease
- Author Affiliation: Harvard Medical School, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts.
Since this article does not have an abstract, we have provided the first 150 words of the full text.
SUMMARY OF THE ORIGINAL ARTICLE
Regional Ileitis, A Pathologic and Clinical Entity
Burrill B. Crohn, MD; Leon Ginzburg, MD; Gordon D. Oppenheimer, MD
This article describes, in clinical and pathologic detail, a disease of the terminal ileum characterized by a subacute or chronic necrotizing and cicatrizing inflammation. The ulceration is reported to be accompanied by a disproportionate connective tissue reaction of the involved intestinal wall, which frequently leads to stenosis of the lumen and is associated with the formation of multiple fistulas.
The disease is clinically featured by symptoms resembling those of ulcerative colitis, ie, fever, diarrhea, emaciation, and a mass in the right iliac fossa usually requiring surgical resection. The etiology is unknown.
See PDF for full text of the original JAMA article.
In a 1932 issue of JAMA, Crohn, Ginzburg, and Oppenheimer1 brought into clear focus a new clinical entity with characteristic pathologic features that …
