Computed Tomographic Colonography for Detecting Advanced Neoplasia—Reply
- Giovanni Galatola, MD;
- Cristiana Laudi, MD cristiana.laudi@ircc.itGastroenterology Unit;
- Daniele Regge, MDRadiology UnitInstitute for Cancer Research and TreatmentCandiolo, Turin, Italy
Since this article does not have an abstract, we have provided the first 150 words of the full text.
- KEYWORDS:
- ADENOMA
- COLONIC NEOPLASMS
- COLONOGRAPHY, COMPUTED TOMOGRAPHIC
- COLONOSCOPY
- COLORECTAL NEOPLASMS
- DIAGNOSIS
- DIAGNOSTIC IMAGING
- PATIENT ADHERENCE
- PRECANCEROUS CONDITIONS
- RISK FACTORS
- TOMOGRAPHY, X-RAY COMPUTED
In Reply: We agree with Dr Matuchansky that flat lesions are important to consider regarding colorectal cancer development and prevention, particularly in persons with a positive family history. In our study, we excluded patients with the highest family risk of cancer: those with criteria for hereditary nonpolyposis colorectal cancer syndrome, who have the highest likelihood of developing aggressive flat lesions. Our article did not consider the diagnostic value for flat lesions, but these data are under analysis. Preliminary results1 for 738 individuals with polyps found 39 flat lesions (5.3%) according to the definition used by Matuchansky; this prevalence is consistent with what would be expected having excluded individuals with the highest risk of flat lesions. The study by Soetikno et al2 found a 9.4% average prevalence of flat/depressed lesions in a mixed population, ranging from 5.8% to 15.4% depending on the risk category. Sensitivity of CT colonography for …
