Updated Analysis of Gene Variants Associated With Deep Vein Thrombosis
- Irene D. Bezemer, PhDDepartment of Clinical EpidemiologyLeiden University Medical CenterLeiden, the Netherlands;
- Lance A. Bare, PhD;
- Andre R. Arellano, BSCeleraAlameda, California;
- Pieter H. Reitsma, PhDEinthoven Laboratory for Experimental Vascular MedicineLeiden University Medical Center;
- Frits R. Rosendaal, MD, PhD f.r.rosendaal@lumc.nlDepartment of Clinical EpidemiologyLeiden University Medical Center
Since this article does not have an abstract, we have provided the first 150 words of the full text.
- KEYWORDS:
- DATA INTERPRETATION, STATISTICAL
- GENETIC PREDISPOSITION TO DISEASE
- POLYMORPHISM, SINGLE NUCLEOTIDE
- RISK FACTORS
- VENOUS THROMBOSIS
To the Editor: A single-nucleotide polymorphism (SNP) association study1 assessing variants associated with deep vein thrombosis found that, of 19 682 gene-centric SNPs, 18 were consistently associated with deep vein thrombosis in the Leiden Thrombophilia Study (LETS) and in a subset of the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis (MEGA-1). Nine of these SNPs were genotyped in the remaining part of the MEGA study (MEGA-2). Assays for the other 9 SNPs for MEGA-2 were not available at that time; the associations of these 9 SNPs with venous thrombosis in 1314 cases and 2877 controls of MEGA-2 were subsequently assessed.
Methods
Details of the study population, DNA collection, SNP selection, and genotyping were described previously.1 Chromosome 1 associations were stratified by factor V Leiden (rs6025, chr 1:167,785,673) to avoid reporting false-positive associations due to linkage disequilibrium. This analysis was previously performed for rs2227589 (SERPINC1 [NCBI …
