Canned Soup Consumption and Urinary Bisphenol A: A Randomized Crossover Trial
- Jenny L. Carwile, MPH;
- Xiaoyun Ye, MS;
- Xiaoliu Zhou, MS;
- Antonia M. Calafat, PhD;
- Karin B. Michels, ScD, PhD
- Author Affiliations: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (Ms Carwile); National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia (Mss Ye and Zhou and Dr Calafat); and Obstetrics and Gynecology Epidemiology Center, Harvard Medical School, Boston (Dr Michels) (kmichels@rics.bwh.harvard.edu).
Since this article does not have an abstract, we have provided the first 150 words of the full text.
To the Editor: Human exposure to bisphenol A (BPA) is widespread.1 In adults, urinary BPA concentrations are positively associated with cardiovascular disease and diabetes.2 Exposure occurs primarily through the diet.3 Bisphenol A has been quantified in many canned goods,4,5 where it is present as a by-product of interior epoxy coatings used to prevent corrosion. We hypothesized that canned soup consumption would increase urinary BPA concentrations relative to fresh soup consumption.
Methods
In 2010, we recruited Harvard School of Public Health (HSPH) student and staff volunteers (aged >18 years) via informational fliers and e-mail. The study was approved by the HSPH institutional review board. Written informed consent was obtained.
We used a randomized, single-blinded, 2 × 2 crossover design. For the first 5-day period (October 25-29, 2010), one group consumed a 12-ounce serving of fresh soup (prepared without canned ingredients) daily between 12:15 and 2 PM; the …
