A COMPARISON OF RECTAL WITH COLON INJECTIONS OF EPINEPHRIN
WITH REFERENCE TO PRESSOR EFFECTS AND TO GLYCOSURIA
- HENRY G. BARBOUR, M.D.;
- FREDERICK H. RAPOPORT, M.D.
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
Although drugs used for their systemic action are frequently given by rectum, distinctions between the results of high (colonic) or low rectal administration apparently have not been sought. The significance of such a discrimination lies in the anatomic fact that absorption from the terminal portion of the mammalian intestine takes place by way of the middle and inferior hemorrhoidal veins directly into a branch of the vena cava. The colon, on the other hand, is drained by the portal system; before the general circulation is reached, a barrier is interposed by the liver and its capillaries. The two extremes of the alimentary canal present its only absorption areas where such protection is not afforded.
Epinephrin was selected for a comparison of colonic and of rectal administration for a number of reasons. At the time (1916) of carrying out the experiments herein described, the literature apparently contained no reference to the
Footnotes
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The expenses of this research were defrayed from the Francis E. Loomis Research Fund of the Yale University School of Medicine.
