Rotating 3-dimensional Fluorodeoxyglucose F18–Positron Emission Tomography Whole-Body Maximal Intensity Projection Image

Supplement to Masciari S, Van den Abbeele AD, Diller LR, et al. F18-Fluorodeoxyglucose–Positron Emission Tomography/Computed Tomography Screening in Li-Fraumeni Syndrome. JAMA. 2008;299(11):1315-1319.

This animated figure supplement displays a rotating whole-body maximal intensity projection image of an individual with Li-Fraumeni Syndrome and gastroesophageal junction cancer.

Overview of Reverse Cholesterol Transport and High Density Lipoprotein Metabolism

Supplement to Singh IM, Shishehbor MH, Ansell BJ. High-Density Lipoprotein as a Therapeutic Target: A Systematic Review. JAMA. 2007;298(7):786-798.

This animated figure supplement provides an overview of how high-density lipoprotein may protect against cardiovascular disease through the mechanism of reverse cholesterol transport.

Interactive Anatomical Model of the Normal L4-5 Functional Spinal Unit and Associated Neural Structures

Supplement to Rathmell JP. A 50-Year-Old Man With Chronic Low Back Pain. JAMA. 2008;299(17):2066-2077.

This interactive model of the normal functional spinal unit displays the anatomical relationships between the L4 and L5 vertebrae and the cauda equina and associated spinal nerves.

Model of Influenza B Neuraminidase Monomer

Supplement to Hatakeyama S, Sugaya N, Ito M. Emergence of Influenza B Viruses With Reduced Sensitivity to Neuraminidase Inhibitors. JAMA. 2007;297:1435-1442.

This interactive supplement is a rotatable model of an influenza B neuraminidase monomer that demonstrates the location of mutations associated with reduced sensitivity to neuraminidase inhibitors.

3D Model of Basal Ganglia

Supplement to Voelker R. Scientists Use Neuroimaging, Genetic Studies to Probe Biology of Tourette Syndrome. JAMA. 2004;292:909-911.

This interactive supplement is a rotatable 3-dimensional computer model of the caudate, putamen, and globus pallidus, in which surface structures were extracted automatically from magnetic resonance imaging data.

Ligamentous and Meniscal Injuries of the Knee: Basic Anatomy and Functional Examination

Supplement to Solomon DH, Simel DL, Bates DW, Katz JN, Schaffer JL. Does This Patient Have a Torn Meniscus or Ligament of the Knee? JAMA. 2001;286:1610-1620.

This interactive module illustrates knee anatomy and demonstrates maneuvers used to perform a thorough functional examination of the knee.

Use of Indigo Carmine Solution in Endoscopic Identification and Resection of Nonpolypoid Colorectal Neoplasms

Video supplement to Soetikno RM, Kaltenbach T, Rouse RV et al. Prevalence of Nonpolypoid (Flat and Depressed) Colorectal Neoplasms in Asymptomatic and Symptomatic Adults. JAMA. 2008;299(9):1027-1035.

This video supplement demonstrates the use of indigo carmine solution to identify a flat, nonpolypoid adenoma followed by endoscopic mucosal resection of the lesion.

A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages

Video supplement to Brust, J. A 74-Year-Old Man With Memory Loss and Neuropathy Who Enjoys Alcoholic Beverages. JAMA. 2008;299(9):1046-1054.

In this video supplement, Mr E describes the loss of strength and function he has experienced in his hands and demonstrates atrophy of the intrinsic muscles of his hands and claw deformities of his fourth and fifth fingers. The video also shows the examination of Mr E's gait.

Transthoracic Echocardiogram of a Patient With Sickle Cell Disease and Pulmonary Hypertension

Video supplement to Barnett CF, Hsue PY, and Machado RF. Pulmonary Hypertension: An Increasingly Recognized Complication of Hereditary Hemolytic Anemias and HIV Infection. JAMA. 2008;299(3):324-331.

This video supplement includes the 2-dimensional and color doppler echocardiograms of the case patient with sickle cell disease and pulmonary hypertension presented in the companion JAMA article.

Echocardiogram of a Patient With Cardiac Tamponade

Supplement to Roy CL, Minor MA, Brookhart MA, Choudhry NK. Does This Patient With a Pericardial Effusion Have Cardiac Tamponade? JAMA. 2007;297:1810-1818.

In this video supplement, a large circumferential pericardial effusion compressing the heart is visualized by transthoracic echocardiography in a patient with cardiac tamponade.

Detection of Patent Foramen Ovale Using Contrast Transesophageal Echocardiography

Supplement to Allemann Y, Hutter D, Ernst L, et al. Patent Foramen Ovale and High-Altitude Pulmonary Edema. JAMA. 2006;296:2954-2958.

This video supplement demonstrates the detection of a patent foramen ovale using contrast transesophageal echocardiography in the long axis view.

3D Imaging of Head and Neck Vasculature

Supplement to Zeller JL. New 3D Imaging Software Opens New Vistas. JAMA. 2006;296:2908-2913.

This supplement shows a video capture of 3D imaging of the vasculature of the head and neck created from noncontrast magnetic resonance imaging data.

Doppler Auscultation of the Posterior Tibial Artery

Supplement to Khan NA, Rahim SA, Anand SS, Simel DL, Panju A. Does the Clinical Examination Predict Lower Extremity Peripheral Arterial Disease? JAMA. 2006;295:536-546.

This audiovisual supplement displays the anatomy, technique, and sound characteristics of Doppler auscultation of the posterior tibial artery of a healthy individual.

Intravascular Ultrasound to Measure Progression of Atherosclerosis

Supplement to Nissen SE, Tuzcu EM, Schoenhagen P. Effect of Intensive Compared With Moderate Lipid-Lowering Therapy on Progression of Coronary Atherosclerosis. JAMA. 2004;291:1071-1080.

This video supplement demonstrates the technique of intravascular ultrasound imaging and determination of atheroma area before and after lipid-lowering therapy.

Mitochondrial Movement in a Cortical Neuron

Supplement to Friedrich MJ. Scientists Probe Roles of Mitochondria in Neurological Disease and Injury. JAMA. 2004;291:679-681.

This time-lapse movie shows mitochondria moving along the cytoskeleton of a single cortical neuron transfected with mitochondrially targeted yellow fluorescent protein.

Use of Augmented Reality for Laparoscopic Adrenalectomy

Supplement to Marescaux J. Augmented-Reality–Assisted Laparoscopic Adrenalectomy. JAMA. 2004;292:2214-2215.

This video demonstrates the preoperative and intraoperative use of augmented reality for laparoscopic adrenalectomy in a patient with Conn adenoma.